Complex Allylation by the Direct Cross‐Coupling of Imines with Unactivated Allylic Alcohols
- 28 April 2009
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 48 (20) , 3648-3652
Abstract
Regioselective, stereoselective: The convergent coupling of allylic alcohols with imines to deliver stereodefined homoallylic amines is described (see scheme). The process proceeds with net allylic transposition without the intermediacy of allylic organometallic reagents. Two stereodefined centers and a geometrically defined di‐ or trisubstituted alkene are forged with high selectivity. magnified imageKeywords
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