Photo-crosslinking of doped magic-sized nanoclusters for the construction of enhanced electrochemiluminescence biosensors

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Abstract
Semiconductor magic-sized nanoclusters (MSCs) possess atomic-level compositional precision and ultrasmall dimensions, allowing accurate modulation of electrochemiluminescence (ECL) properties, essential for advanced bioanalytical applications. However, low intrinsic ECL intensity and poor stability in bipolar electrode (BPE)-ECL systems hinder their broader use. In this work, we addressed these limitations through doping and direct optical crosslinking strategies, achieving a 24-fold boost in the ECL signal and a fivefold stability increase for doped (CdS)34:Ag MSCs compared with original (CdS)34 MSCs. The resulting BPE-ECL biosensing platform was used for the sensitive detection of glucose with a linear detection range of 10 μM to 1 mM and a detection limit of 3.64 μM. This approach provides a robust strategy to enhance MSC-based ECL biosensing, paving the way for ultrasensitive, stable biosensors for clinical diagnostics and bioanalysis.
Funding Information
  • National Key Research and Development Program of China (2022YFC3401802)
  • Jiangsu Agricultural Science and Technology Innovation Fund (CX(24)3036)
  • China Postdoctoral Science Foundation (2024M751389)
  • National Natural Science Foundation of China (22171132)
  • National Natural Science Foundation of China (52472165)
  • National Natural Science Foundation of China (22276100)
  • Nanjing University of Posts and Telecommunications (NY221006)
  • Science and Technology Support Program of Jiangsu Province (BK20232041)
  • Science and Technology Support Program of Jiangsu Province (BK20220405)
  • Science and Technology Support Program of Jiangsu Province (BK20241024)

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