Calcium-dependent transcription of cytokine genes in T lymphocytes
Authors:
- 2 March 2007
- journal article
- review article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 454 (4) , 523-533
Abstract
The increase in intracellular calcium ion concentration is a general signaling mechanism used in many biological systems. In T lymphocytes, calcium is essential for activation, differentiation, and effector functions. In this study, we will summarize recent developments of how intracellular calcium concentrations are modified in T cells to affect the activity of three major calcium-dependent transcriptional effectors, i.e., NFAT, MEF2, and DREAM, involved in cytokine gene expression.Keywords
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