Intermolecular Interactions in Collagen Self-Assembly as Revealed by Fourier Transform Infrared Spectroscopy

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Abstract
When a solution of collagen molecules, at neutral p H and moderate ionic strength, is warmed from 4° to 30°C, a spontaneous self-assembly process takes place in which native-type collagen fibers are produced. Events occurring during thermally induced fibrillogenesis process can be monitored, in aqueous media and in real time, by Fourier transform infrared spectroscopic techniques. Tentative assignments of observed spectral bands are given.

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