IS Ecp1 -Mediated Transposition and Homologous Recombination Can Explain the Context of bla CTX-M-62 Linked to qnrB2
- 1 July 2010
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 54 (7) , 3039-3042
Abstract
bla CTX-M-62 , a C508T variant of bla CTX-M-3b , was transferred from Klebsiella pneumoniae JIE137 on a conjugative plasmid together with a class 1 integron containing the dfrA12 - gcuF - aadA2 cassette array, IS CR1 , and qnrB2 . bla CTX-M-62 lies between intact and rearranged copies of IS Ecp1 in a configuration that can be explained by a combination of transposition and homologous recombination and which also illustrates the ability of IS Ecp1 to mobilize an adjacent gene as part of transposition units of different sizes.Keywords
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