Serum Cyclosporine Concentration and Risk of Acute Graft-versus-Host Disease after Allogeneic Marrow Transplantation
Authors:
- Steven G. SelfSSSteven G. Self
- Timothy R. McGuireTMTimothy R. McGuire
- Julie CarlinJCJulie Carlin
- Jean E. SandersJSJean E. Sanders
- H. Joachim DeegHDH. Joachim Deeg
- 14 July 1988
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 319 (2) , 65-70
Abstract
To determine the relation between the serum cyclosporine concentration and the risk of acute graft-versus-host disease (GVHD), we studied 179 recipients of bone marrow grafts from HLA-identical sibling donors who received prophylaxis with cyclosporine, either by itself or combined with methotrexate. Cyclosporine was given either orally or intravenously at full doses from the day before transplantation until day 50; it was then tapered off and discontinued on day 180. Trough concentrations of serum cyclosporine were measured by radioimmunoassay. The relation between patients' characteristics and the risk of acute GVHD was analyzed with a relative-risk regression model.Keywords
This publication has 25 references indexed in Scilit:
- IN VITRO IMMUNOSUPPRESSIVE PROPERTIES OF CYCLOSPORINE METABOLITESTransplantation, 1987
- IMMUNOSUPPRESSIVE METABOLITES OF CYCLOSPORINE IN THE BLOOD OF RENAL ALLOGRAFT RECIPIENTSTransplantation, 1986
- Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for LeukemiaNew England Journal of Medicine, 1986
- Risk Factors for Cytomegalovirus Infection after Human Marrow TransplantationThe Journal of Infectious Diseases, 1986
- Marrow Transplantation from Related Donors Other Than HLA-Identical SiblingsNew England Journal of Medicine, 1985
- Oral administration of cyclosporin A for recipients of allogeneic marrow transplants: implications of clinical gut dysfunctionBritish Journal of Haematology, 1984
- CYCLOSPORINE IN HUMAN BONE MARROW TRANSPLANTATION SEKUM CONCENTRATION, GRAFT-VERSUS-HOST DISEASE, AND NEPHROTOXICITYTransplantation, 1983
- Graft-versus-Host Disease and Survival in Patients with Aplastic Anemia Treated by Marrow Grafts from HLA-Identical SiblingsNew England Journal of Medicine, 1983
- Cyclosporin A as prophylaxis against graft-versus-host disease in 36 patients.BMJ, 1982
- IMMUNOLOGICAL AND PHARMACOLOGICAL MONITORING IN THE CLINICAL USE OF CYCLOSPORIN AThe Lancet, 1981