High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19

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Abstract
Significance: Accumulating evidence shows that granulocytes are key modulators of the immune response to SARS-CoV-2 infection, and their dysregulation could significantly impact COVID-19 severity and patient recovery after virus clearance. In the present study, we identify selected immune traits in neutrophil, eosinophil, and basophil subsets associated with severity of COVID-19 and with peripheral protein profiles. Moreover, computational modeling indicates that the combined use of phenotypic data and laboratory measurements can effectively predict key clinical outcomes in COVID-19 patients. Finally, patient-matched longitudinal analysis shows phenotypic normalization of granulocyte subsets 4 mo after hospitalization. Overall, in this work, we extend the current understanding of the distinct contribution of granulocyte subsets to COVID-19 pathogenesis.
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Funding Information
  • Barncancerfonden (TJ2018-0128, PR2019-0100)
  • Ake Olsson Foundation for Haematological research (-)
  • Karolinska Institutet (2018-02290)
  • Karolinska Institutet (-)
  • Nordstjernan AB (-)
  • Knut och Alice Wallenbergs Stiftelse (-)
  • Vetenskapsrådet (2020-01371)
  • Ake Olsson Foundation for Haematological research (2020-00301)
  • Karolinska Institutet (2020-01449)
  • CIMED (20200313)
  • Stiftelsen Clas Groschinskys Minnesfond (M-2031)
  • NordForsk (90456)
  • Vetenskapsrådet (2018-151)
  • CIMED (-)
  • Vetenskapsrådet (-)
  • Cancerfonden (-)

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