Potassium channels from NG108‐15 neuroblastoma‐glioma hybrid cells
Authors:
- Keiji ImotoKIKeiji Imoto
- Tetsuro KawamuraTKTetsuro Kawamura
- Haruhiro HigashidaHHHaruhiro Higashida
- Naoyuki IwabeNINaoyuki Iwabe
- Takashi MiyataTMTakashi Miyata
- Shosaku NumaSNShosaku Numa
- 18 December 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 259 (1) , 37-42
Abstract
The complete amino acid sequences of two potassium channel proteins from NG108‐15 neuroblastoma‐glioma hybrid cells have been deduced by cloning and sequencing the cDNAs. One of these proteins (NGK2) is structurally more closely related to the Drosophila Shaw gene product than to the Shaker and Shab gene products, whereas the other (NGK1) is identical with a rat brain potassium channel protein (BK2) which is more closely related to the Drosophila Shaker gene product. mRNAs derived from both the cloned cDNAs, when injected into Xenopus oocytes, direct the formation of functional potassium channels with properties of delayed rectifiers.Keywords
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