Evaluation of the Preparation Technology on Chitosan-Gelatin Microcarrier by Orthogonal Design

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Abstract
This article presents the optimization of process parameters in chitosan-gelatin composite microcarriers preparation based on multi-index test breakdown formula evaluation combined with orthogonal array. In this study, the concentration of crosslinker solution, the concentration of water phase and stirring speed were considered as controllable factors, and three levels for each of these factors were selected, in an L9 orthogonal array. The optimal levels of the process parameters were determined through the range analysis and the relative importance among the process parameters were identified through analysis of variance. According to the evaluations of particle size, morphological analysis, compressibility, and equilibrium swelling from the nine different sets, the optimum combinations for microcarriers preparation were showed as: the concentration of crosslinker solution:0.5% (wt/v), the concentration of water phase:5% (wt/v) and stirring speed:240 rpm.

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