Directed ortho-metalation and Suzuki–Miyaura cross-coupling connections: regiospecific synthesis of all isomeric chlorodihydroxybiphenyls for microbial degradation studies of PCBs

Authors:
  • SNS. Nerdinger
    S. Nerdinger
  • RMR. Marchhart
    R. Marchhart
  • PRP. Riebel
    P. Riebel
  • CKC. Kendall
    C. Kendall
  • MJM. R. Johnson
    M. R. Johnson
  • CYC.-F. Yin
    C.-F. Yin
  • VSV. Snieckus
    V. Snieckus
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Abstract
Monochloro DHBs 1a–d and 2a–c have been regioselectively synthesised in good overall yields by a combination of directed ortho metalation and Suzuki–Miyaura cross-coupling.