Modulation of MnSOD in Cancer: Epidemiological and Experimental Evidences
Author:
Open Access
- 1 June 2010
- journal article
- review article
- Published by Springer Nature in Toxicological Research
- Vol. 26 (2) , 83-93
Abstract
Modulation of MnSOD in Cancer: Epidemiological and Experimental Evidences MnSOD;Mitochondria;Superoxide anion;Hydrogen peroxide;Oxidative stress;Redox;Cancer;Epidemiology;Carcinogenesis; Since it was first observed in late 1970s that human cancers often had decreased manganese superoxide dismutase (MnSOD) protein expression and activity, extensive studies have been conducted to verify the association between MnSOD and cancer. Significance of MnSOD as a primary mitochondrial antioxidant enzyme is unquestionable; results from in vitro, in vivo and epidemiological studies are in harmony. On the contrary, studies regarding roles of MnSOD in cancer often report conflicting results. Although putative mechanisms have been proposed to explain how MnSOD regulates cellular proliferation, these mechanisms are not capitulated in epidemiological studies. This review discusses most recent epidemiological and experimental studies that examined the association between MnSOD and cancer, and describes emerging hypotheses of MnSOD as a mitochondrial redox regulatory enzyme and of how altered mitochondrial redox may affect physiology of normal as well as cancer cells.Keywords
This publication has 102 references indexed in Scilit:
- Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxinFree Radical Biology and Medicine, 2010
- Regulation of superoxide dismutase genes: Implications in diseaseFree Radical Biology and Medicine, 2009
- Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/MifepristoneExperimental Gerontology, 2007
- Manganese superoxide dismutase Ala-9Val polymorphism, environmental modifiers, and risk of breast cancer in a German populationCancer Causes & Control, 2006
- A New Paradigm: Manganese Superoxide Dismutase Influences the Production of H2O2 in Cells and Thereby Their Biological StateFree Radical Biology and Medicine, 2006
- Potent Anti-tumor Effects of an Active Site Mutant of Human Manganese-Superoxide DismutaseJournal of Biological Chemistry, 2004
- Analysis of Mitochondrial Targeting Sequence and Coding Region Polymorphisms of the Manganese Superoxide Dismutase Gene in German Parkinson Disease PatientsBiochemical and Biophysical Research Communications, 1999
- Inhibition of cell growth in NIH/3T3 fibroblasts by overexpression of manganese superoxide dismutase: Mechanistic studiesJournal of Cellular Physiology, 1998
- Cell division in normal and transformed cells: The possible role of superoxide and hydrogen peroxideMedical Hypotheses, 1981
- Cell differentation, aging and cancer: The possible roles of superoxide and superoxide dismutasesMedical Hypotheses, 1980