The secretases that cleave angiotensin converting enzyme and the amyloid precursor protein are distinct from tumour necrosis factor‐α convertase
Authors:
- Eric H KarranEKEric H Karran
- Anthony J TurnerATAnthony J Turner
- Nigel M HooperNigel M Hooper
- 10 July 1998
- journal article
- Published by Wiley in FEBS Letters
- Vol. 431 (1) , 63-65
Abstract
Angiotensin converting enzyme (ACE) and the Alzheimer's amyloid precursor protein are cleaved from the membrane by zinc metalloproteinases termed ACE secretase and α‐secretase, respectively. Tumour necrosis factor‐α (TNF‐α) convertase (ADAM 17) is a recently identified member of the adamalysin family of mammalian zinc metalloproteinases that is involved in the production of TNF‐α and possibly in the cleavage of other membrane proteins. Using two different cell‐free assays we were unable to detect significant cleavage and secretion of ACE by TNF‐α convertase. In addition, there was a different effect of three hydroxamic acid‐based inhibitors (batimastat, compound 1 and compound 4) towards TNF‐α convertase as compared to ACE secretase and α‐secretase. Thus TNF‐α convertase would appear to be distinct from, but possibly related to, the secretases that cleave ACE and the amyloid precursor protein.Keywords
This publication has 23 references indexed in Scilit:
- MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELSAnnual Review of Neuroscience, 1998
- Alzheimer's Amyloid Precursor Protein α-Secretase Is Inhibited by Hydroxamic Acid-Based Zinc Metalloprotease Inhibitors: Similarities to the Angiotensin Converting Enzyme SecretaseBiochemistry, 1998
- Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and NotchCell, 1997
- Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-αNature, 1997
- A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cellsNature, 1997
- Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's DiseaseJournal of Neurochemistry, 1995
- Generation of amyloid β protein from its precursor is sequence specificNeuron, 1995
- Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processingNature, 1994
- Cleavage of Amyloid β Peptide During Constitutive Processing of Its PrecursorScience, 1990
- A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: Ramifications for the complex physiology of TNFCell, 1988