Bovine leptospirosis: The detection of haemolysin inhibitors in sera from experimentally and naturally infected cattle

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  • RHR.T. Hodges
    R.T. Hodges
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Abstract
Extract Strains of some serotypes of Leptospira produce, haemolysins with strong affinities for ruminant erythrocytes. The haemolysins are heat-labile, effective against erythrocytes after relatively long periods of incubation, and generally concentrated in extracellular culture fluids (Russell, 1956 Russell, C. M. 1956. A “haemolysin” associated with leptospirae. J. Immun., 79: 405–409. [Google Scholar] ; Alexander et al., 1956 Alexander, A. D. , Smith, O. H. , Hiatt, C. W. and Gleiser, C. A. 1956. Presence of haemolysin in cultures of pathogenic leptospires. Proc. Soc. exp. Biol. Med., 91: 205–211. [Google Scholar] ; Valentine et al., 1964 Sullivan, N. D. 1970. Experimental infection of cattle with Leptospira hardjo. Aust. vet. J., 46: 121–122. [Crossref], [PubMed], [Web of Science ®] [Google Scholar] ). Russell ( 1956 Russell, C. M. 1956. A “haemolysin” associated with leptospirae. J. Immun., 79: 405–409. [Google Scholar] ) reported that sera of rabbits immunized with a haemolysin producing strain of serotype pomona contained, in addition to agglutinins, inhibitors which neutralized the effects of the haemolysin. No corresponding studies in cattle appear to have been reported.

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