NMR Analysis of Quinocycline Antibiotics: Structure Determination of Kosinostatin, an Antitumor Substance from Micromonospora sp. TP-A0468.
Open Access
- 1 January 2002
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 55 (2) , 134-140
Abstract
A quinocycline antibiotic, kosinostatin, was isolated from the culture broth of Micromonospora sp. TP-A0468 along with isoquinocycline B. Structure of kosinostatin was determined to be the stereoisomer of isoquinocycline B regarding to the stereochemistry at the C-2' spiro carbon by NMR analysis. Kosinostatin isomerizes to isoquinocycline B through the inversion of the stereocenter at C-2'. Comparison of physico-chemical properties indicated that kosinostatin is presumably identical with quinocycline B isolated by CELMER et al. from Streptomyces aureofaciens.Keywords
This publication has 2 references indexed in Scilit:
- Kosinostatin, a Quinocycline Antibiotic with Antitumor Activity from Micromonospora sp. TP-A0468.The Journal of Antibiotics, 2002
- Structure of the Sugar Components of the Quinocycline ComplexEuropean Journal of Biochemistry, 1972