Structural Study‐Guided Development of Versatile Phase‐Transfer Catalysts for Asymmetric Conjugate Additions of Cyanide
Authors:
- 14 September 2011
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 50 (45) , 10565-10569
Abstract
Unprecedented phase‐transfer catalysts for the first example of an organocatalytic asymmetric conjugate addition of cyanide with acetone cyanohydrin are reported (see scheme). Utilizing an accessible cupreidinium salt and a cyanation reagent suitable for industrial scale, this reaction holds significant promise for practical asymmetric synthesis. The catalysts were developed as a result of key structural insights gained by X‐ray analysis.Keywords
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