Synthesis of Lactams via Copper-Catalyzed Intramolecular Vinylation of Amides
Authors:
- 9 April 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 7 (10) , 2035-2038
Abstract
Copper-catalyzed intramolecular vinylation of iodoenamides were investigated for the first time. With CuI as the catalyst and N,N‘-dimethylethylenediamine as the ligand, a number of iodoenamides underwent cyclization in dioxane leading to the formations of five- to seven-membered lactams in moderate to excellent yields.Keywords
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