Monocyte chemoattractant protein-1 (MCP-1) g.-2518A>Gpolymorphism and susceptibility to type 2 diabetes (T2D) and end stage renal disease (ESRD) in the North-West Indian population of Punjab

Authors:
  • KMKawaljit Matharoo
    Kawaljit Matharoo
  • ABA. J. S. Bhanwer
    A. J. S. Bhanwer
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Abstract
Diabetic nephropathy (DN) is a major microvascular complication that develops in nearly 20-30% of patients with type 2 diabetes (T2D) and is currently the leading cause of end stage renal disease (ESRD). Monocyte chemoattractant protein-1 (MCP-1), a potent chemokine secreted by adipocytes, has been implicated as a causal factor in the progression of vascular complications in T2D, thus MCP-1 appears to be a promising candidate for association study. The objective of the present study is to evaluate the association, if any, of g.-2518A>G polymorphism (rs1024611) in MCP-1 gene in T2D cases with and without ESRD in the population of Punjab from North-West India. A total of 571 samples from Punjab comprising 350 T2D cases (145 with ESRD and 205 without ESRD) and 221 controls were genotyped for g.-2518A>G MCP-1 polymorphism using amplification refractory mutation system- polymerase chain reaction. The frequency of G allele was observed to be higher in T2D cases with ESRD (34.49%) compared to T2D cases without ESRD (24.39%) and controls (31.67%). Under the dominant model, G allele increased the risk of ESRD by 1.68-fold [p = 0.047, OR = 1.68 (1.0-2.79) at 95% CI]. MCP-1 -2518 GG genotype and G allele may increase the risk of progression to ESRD in T2D cases.

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