Further study of the role of calcium in synaptic transmission
Authors:
- B. KatzBKB. Katz
- R. MilediRMR. Miledi
- 1 May 1970
- journal article
- Published by Wiley in The Journal of Physiology
- Vol. 207 (3) , 789-801
Abstract
1. The effect of calcium on synaptic transmission has been studied by intracellular recording of pre‐ and post‐synaptic potential changes in the stellate ganglion of the squid.2. For a given presynaptic ‘input’ (propagated spike, or local depolarizing pulse after tetrodotoxin treatment), the post‐synaptic response increases with external calcium concentration [Ca]o in a highly non‐linear fashion, indicating that transmitter output varies with more than the second power of [Ca]o over a certain concentration range.Keywords
This publication has 9 references indexed in Scilit:
- Tetrodotoxin‐resistant electric activity in presynaptic terminalsThe Journal of Physiology, 1969
- On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulsesThe Journal of Physiology, 1968
- Co‐operative action of calcium ions in transmitter release at the neuromuscular junctionThe Journal of Physiology, 1967
- A study of synaptic transmission in the absence of nerve impulsesThe Journal of Physiology, 1967
- Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squidThe Journal of Physiology, 1967
- The action of calcium on neuronal synapses in the squidThe Journal of Physiology, 1966
- Effects of calcium on the conductance change of the end‐plate membrane during the action of transmitterThe Journal of Physiology, 1963
- The nature of the antagonism between calcium and magnesium ions at the neuromuscular junctionThe Journal of Physiology, 1957
- A further study of the statistical composition of the end‐plate potentialThe Journal of Physiology, 1955