EcoCyc: fusing model organism databases with systems biology
Authors:
- Ingrid M. KeselerIKIngrid M. Keseler
- Amanda MackieAMAmanda Mackie
- Martin Peralta-GilMPMartin Peralta-Gil
- Alberto Santos-ZavaletaASAlberto Santos-Zavaleta
- Socorro Gama-CastroSGSocorro Gama-Castro
- César Bonavides-MartínezCBCésar Bonavides-Martínez
- Carol FulcherCFCarol Fulcher
- Araceli M. HuertaAHAraceli M. Huerta
- Anamika KothariAKAnamika Kothari
- Markus KrummenackerMKMarkus Krummenacker
- Mario LatendresseMLMario Latendresse
- Luis Muñiz-RascadoLMLuis Muñiz-Rascado
Top Cited Papers
Open Access
- 7 November 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 41 (D1) , D605-D612
Abstract
EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E. coli gene products in EcoCyc has been based on information found in the experimental literature for E. coli K-12-derived strains. Updates to EcoCyc content continue to improve the comprehensive picture of E. coli biology. The utility of EcoCyc is enhanced by new tools available on the EcoCyc web site, and the development of EcoCyc as a teaching tool is increasing the impact of the knowledge collected in EcoCyc.Keywords
This publication has 29 references indexed in Scilit:
- RegPrecise web services interface: programmatic access to the transcriptional regulatory interactions in bacteria reconstructed by comparative genomicsNucleic Acids Research, 2012
- Comparative multi-omics systems analysis of Escherichia coli strains B and K-12Genome Biology, 2012
- Construction and completion of flux balance models from pathway databasesBioinformatics, 2012
- The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of pathway/genome databasesNucleic Acids Research, 2011
- The evolution of metabolic networks of E. coliBMC Systems Biology, 2011
- Experimental and Computational Assessment of Conditionally Essential Genes inEscherichia coliJournal of Bacteriology, 2006
- Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collectionMolecular Systems Biology, 2006
- Highly accurate genome sequences of Escherichia coli K‐12 strains MG1655 and W3110Molecular Systems Biology, 2006
- Escherichia coli K-12: a cooperatively developed annotation snapshot--2005Nucleic Acids Research, 2006
- TCDB: the Transporter Classification Database for membrane transport protein analyses and informationNucleic Acids Research, 2006