Tripicolylamino-Containing Heterocycles as Potential Sensors for Zinc Cations

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Abstract
The study of 2,2′-bipyridine-like ligands for the creation of sensors for zinc(II) ions was carried out, including for use in biological systems, for which the range of available sensors is currently limited. New derivatives of quinazolin-4(3H)-one and 1,3,4-oxadiazole containing a tripicolylamine moiety were synthesized. Photophysical properties of both these 2,2′-bipyridine-like ligands and their complexes with zinc(II) ions were studied. 2-Substituted quinazolin-4(3H)-one showed itself as a typical PET sensor for zinc cations; a significant increase in the luminescence of an acetonitrile solution was observed upon the addition of zinc(II) perchlorate (from Vero culture cells, including those artificially enriched with zinc, was studied. The possibility of using 2-pyridyl-substituted quinazolin-4(3H)-ones as sensors for zinc(II) ions has been demonstrated; however, further research in this area is required for their effective application in biological environments.

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