LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

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Abstract
Significance: LIN28B is well known as a RNA-binding protein and a suppressor of microRNA biogenesis by selectively blocking the processing of let-7 precursors. However, little is known about let-7 –independent roles of LIN28B. Here, we show that LIN28B is recruited to active promoters by binding to the zinc-finger transcription factor ZNF143. LIN28B acts as a cofactor to upregulate expression of a subset of downstream target genes that are essential for neuroblastoma cell survival and migration. Our paper reveals an unexpected role of LIN28B in transcriptional regulation that is independent of let-7 during neuroblastoma pathogenesis.
Funding Information
  • HHS | National Institutes of Health (R01-CA180692)
  • Alex's Lemonade Stand Foundation for Childhood Cancer (N/A)
  • HHS | National Institutes of Health (R21-HG009268)
  • Hope Funds for Cancer Research (N/A)
  • the American Lebanese Syrian Associated Charities (N/A)
  • Rally Foundation (N/A)
  • Damon Runyon Cancer Research Foundation (DRSG-24-18)
  • Alex's Lemonade Stand Foundation for Childhood Cancer (N/A)
  • CureSearch for Children's Cancer (N/A)

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