Molecular dynamics simulations on the critical states of the farnesyltransferase enzyme
- 1 May 2009
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 17 (9) , 3369-3378
Abstract
No abstract availableKeywords
Funding Information
- Fundação para a Ciência e a Tecnologia (POCI/QUI/61563/2004)
This publication has 88 references indexed in Scilit:
- Caged Protein Prenyltransferase Substrates: Tools for Understanding Protein PrenylationChemical Biology & Drug Design, 2008
- Computational Studies of the Farnesyltransferase Ternary Complex Part II: The Conformational Activation of FarnesyldiphosphateBiochemistry, 2007
- Transition State Analysis of Model and Enzymatic Prenylation ReactionsJournal of the American Chemical Society, 2007
- Enhanced FTase activity achieved via piperazine interaction with catalytic zincBioorganic & Medicinal Chemistry Letters, 2006
- The Protein Farnesyltransferase Inhibitor Tipifarnib as a New Lead for the Development of Drugs against Chagas DiseaseJournal of Medicinal Chemistry, 2005
- Unraveling the mechanism of the farnesyltransferase enzymeJBIC Journal of Biological Inorganic Chemistry, 2004
- Genetic Alterations during Colorectal-Tumor DevelopmentNew England Journal of Medicine, 1988
- Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genesCell, 1988
- ras GENESAnnual Review of Biochemistry, 1987
- A new force field for molecular mechanical simulation of nucleic acids and proteinsJournal of the American Chemical Society, 1984