Parallel manifestation of insulin resistance and beta cell decompensation is compatible with a common defect in Type 2 diabetes
Authors:
- 28 April 2004
- journal article
- research article
- Published by Springer Nature in Diabetologia
- Vol. 47 (5) , 782-793
Abstract
The aim of the study was to evaluate the relationship between insulin sensitivity, beta cell function and glucose tolerance, and its dependence on variants in the newly identified Type 2 diabetes susceptibility gene, calpain-10 (CAPN10).Keywords
This publication has 51 references indexed in Scilit:
- Genetic Variations in Calpain-10 Gene Are Not a Major Factor in the Occurrence of Type 2 Diabetes in JapaneseThe Journal of Clinical Endocrinology & Metabolism, 2003
- Variants Within the Calpain-10 Gene on Chromosome 2q37 (NIDDM1) and Relationships to Type 2 Diabetes, Insulin Resistance, and Impaired Acute Insulin Secretion Among Scandinavian CaucasiansDiabetes, 2002
- Calpains Play a Role in Insulin Secretion and ActionDiabetes, 2001
- Insulin secretion and insulin sensitivity in diabetic subgroups: studies in the prediabetic and diabetic stateDiabetologia, 2000
- A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistanceJournal of Clinical Investigation, 2000
- Impaired Glucose Transport as a Cause of Decreased Insulin-Stimulated Muscle Glycogen Synthesis in Type 2 DiabetesNew England Journal of Medicine, 1999
- Effects of free fatty acids on glucose transport and IRS-1–associated phosphatidylinositol 3-kinase activityJournal of Clinical Investigation, 1999
- Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.Diabetes, 1999
- Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO ConsultationDiabetic Medicine, 1998
- Normal hepatic insulin sensitivity in lean, mild noninsulin-dependent diabetic patients.The Journal of Clinical Endocrinology & Metabolism, 1996