Molecular model of a lattice of signalling proteins involved in bacterial chemotaxis
- 7 October 2000
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 2 (11) , 792-796
Abstract
Coliform bacteria detect chemical attractants by means of a membrane-associated cluster of receptors and signalling molecules. We have used recently determined molecular structures, in conjunction with plastic models generated by three-dimensional printer technology, to predict how the proteins of the complex are arranged in relation to the plasma membrane. The proposed structure is a regular two-dimensional lattice in which the cytoplasmic ends of chemotactic-receptor dimers are inserted into a hexagonal array of CheA and CheW molecules. This structure creates separate compartments for adaptation and downstream signalling, and indicates a possible basis for the spread of activity within the cluster.Keywords
This publication has 42 references indexed in Scilit:
- Structure of CheA, a Signal-Transducing Histidine KinaseCell, 1999
- Bacterial Tactic Responses1999
- Two binding modes reveal flexibility in kinase/response regulator interactions in the bacterial chemotaxis pathwayProceedings of the National Academy of Sciences, 1998
- The use of solid physical models for the study of macromolecular assemblyCurrent Opinion in Structural Biology, 1998
- THE TWO-COMPONENT SIGNALING PATHWAY OF BACTERIAL CHEMOTAXIS: A Molecular View of Signal Transduction by Receptors, Kinases, and Adaptation EnzymesAnnual Review of Cell and Developmental Biology, 1997
- Evaluation of the CASP2 docking sectionProteins: Structure, Function, and Bioinformatics, 1997
- Control of bacterial chemotaxisMolecular Microbiology, 1996
- The Application of stereolithography to the fabrication of accurate molecular modelsJournal of Molecular Graphics, 1995
- Liberation of an interaction domain from the phosphotransfer region of CheA, a signaling kinase of Escherichia coli.Proceedings of the National Academy of Sciences, 1994
- Polar Location of the Chemoreceptor Complex in the Escherichia coli CellScience, 1993