Response to Letter to the Editor on “Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study”

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First and foremost, we extend our sincere gratitude to Zhang et al for their dedication to advancing scientific knowledge. True scientific progress is achieved through iterative research, critical discourse, and persistent pursuit of accurate solutions. We are deeply inspired by the commitment demonstrated by Zhang et al and aspire to emulate their dedication in our future endeavors. It is imperative to acknowledge, however, that while we hold great respect for the perspectives presented by Zhang et al, endorsing them may pose challenges. Whether considering contemporary methodological standards or the findings of previously published Mendelian randomization (MR) studies, convincing a broad audience presents inherent complexities. Their letter lacks sufficient evidence to support their views and urges us, along with many other researchers who have published ED-related MR studies, to reconsider and update our methodologies and article content.

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