Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds

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Abstract
Eight chlorinated alkylresorcinols, monochasiol A–H (1–8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1–8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.
Funding Information
  • Takeda Science Foundation
  • Ministry of Education, Culture, Sports, Science and Technology (16H03279)
  • Japan Agency for Medical Research and Development
  • Shorai Foundation for Science and Technology
  • Kobayashi International Scholarship Foundation

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