A novel nutritional intervention improves lung function in overweight/obese adolescents with poorly controlled asthma: the Supplemental Nutrition in Asthma Control (SNAC) pilot study

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Abstract
Asthma in the obese is often severe, difficult to treat, and characterized by less eosinophilic inflammation than asthma in the nonobese. Obesity‐associated metabolic dysregulation may be a causal factor. We previously reported that a nutrient‐ and fiber‐dense bar [Children's Hospital Oakland Research Institute (CHORI)‐bar], which was designed to fill gaps in poor diets, improved metabolism in healthy overweight/obese (OW/OB) adults. In this pilot trial, OW/OB adolescents with poorly controlled asthma were randomized to weekly nutrition/exercise classes with or without twice‐daily CHORI‐bar consumption. Intent‐to‐treat analysis did not indicate CHORI‐bar‐specific effects. However, restricting the analysis to participants with acceptable compliance and a relatively low fraction of exhaled nitric oxide (FENO; n = 16; controls, n = 15) indicated that CHORI‐bar‐specific, significant improvements in lung function (forced vital capacity, percent‐predicted forced expiratory volume in 1 s, and percent‐predicted forced expiratory flow between 25 and 75% of forced vital capacity), primarily in participants with low chronic inflammation (high‐sensitivity C‐reactive protein FASEB J . 32, 6643–6654 (2018). www.fasebj.org

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