The Chemotherapy of Prostatic Adenocarcinoma
Authors:
- 1 May 1980
- journal article
- clinical trial
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 92 (5) , 681-689
Abstract
A number of chemotherapeutic agents show moderate promise for the palliative treatment of metastatic prostatic carcinoma. Although patterns of metastatic disease make classic response rates difficult to obtain and interpret, doxorubicin, cyclophosphamide, dacarbazine (DTIC), and cisplatin have activity in patients who have failed conventional hormonal treatment. In most studies, a survival advantage is seen for responders to these and other chemotherapeutic agents, but no survival advantage has been seen for the treatment cohorts when compared to groups not receiving chemotherapy. Therefore, estimates of the usefulness of these agents must be considered tentative. Multiple drug therapy has not yet shown definite superiority to single agent treatment. The uses and limitations of acid phosphatase as a tumor marker, as well as particular difficulties in measuring tumor response in the disease, are detailed herein.Keywords
This publication has 51 references indexed in Scilit:
- Cyclophosphamide (NSC 26271) versus the combination of adriamycin (NSC 123127), 5-fluorouracil (NSC 19893), and cyclophosphamide in the treatment of metastatic prostatic cancer. A randomized trialCancer, 1978
- Dose response evaluation of adriamycin in human neoplasiaCancer, 1977
- Operative staging of apparently localized adenocarcinoma of the prostate: Results in fifty unselected patients.I. Experimental design and preliminary resultsCancer, 1976
- Carcinoma of prostate correlation between radiologic quantitation of metastases and patient survivalUrology, 1975
- The natural history of prostatic cancerCancer, 1973
- Non-hormonal cytotoxic agents in the treatment of prostatic adenocarcinomaCancer, 1973
- The veterans administration cooperative urological research group's studies of cancer of the prostateCancer, 1973
- Radical prostatectomy in the treatment of prostatic cancerCancer, 1973
- Orchiectomy for advanced prostatic carcinoma A reevaluationUrology, 1973
- Estrogen treatment for cancer of the prostate.Early results with 3 doses of diethylstilbestrol and placeboCancer, 1970