The Effects of 5-Fluorouracil on Ocular Tissues In Vitro and In Vivo after Controlled Release from a Multifunctional Implant

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Abstract
Purpose. To evaluate the effects of 5-fluorouracil (5-FU) on ocular cells in vitro and the effects of degradable 5-FU–loaded poly(dl-lactide-co-glycolide; PDLGA) 50:50 implant in the rabbit eye in vivo.