Cross talk between oxidative stress and inflammation in alopecia areata

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Abstract
Background: Although the etiopathogenesis of alopecia areata (AA) is still unclear, inflammation, oxidative stress, and subsequent DNA damage might be considered role players in disease development.Aim: We aimed at exploring the potential link between oxidative DNA damage and inflammation in AA patients through measuring 8‐hydroxy deoxyguanosine (8‐OHdG), high mobility group box 1 protein (HMGB1), and one of the inflammatory mediators, C‐reactive protein (CRP).Methods: A total of 79 subjects (49 AA patients in addition to 30 apparently healthy control subjects) were tested for serum levels of 8‐OHdG, HMBG1, and CRP.Results: Compared with the control group, serum 8‐OHdG, HMBG1, and CRP levels were significantly elevated in the studied patients group (0.031, <0.001, and <0.001, respectively). Moreover, logistic regression analysis revealed that disease course, serum levels of 8‐OHdG, and HMBG1 were considered independent predictors for AA severity in both uni‐ and multivariable analyses.Conclusion: Our results suggest a possible role of oxidative stress together with proinflammatory biomarkers in development of AA and their benefit in predicting a severe form of the disease.

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