Self-oligomerization regulates stability of survival motor neuron protein isoforms by sequestering an SCFSlmb degron
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Open Access
- 15 January 2018
- journal article
- research article
- Published by American Society for Cell Biology (ASCB) in Molecular Biology of the Cell
- Vol. 29 (2) , 96-110
Abstract
SMN protein levels inversely correlate with the severity of spinal muscular atrophy. The SCFSlmbE3 ligase complex interacts with a degron embedded within the C-terminal self-oligomerization domain of SMN. The findings elucidate a model whereby accessibility of the SMN degron is regulated by self-multimerization.Keywords
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