Therapeutic Effect of Gypenoside on Chronic Liver Injury and Fibrosis Induced by CCl4 in Rats
Authors:
- 1 January 2000
- journal article
- research article
- Published by World Scientific Pub Co Pte Ltd in The American Journal of Chinese Medicine
- Vol. 28 (02) , 175-185
Abstract
Gypenoside is a saponins extract derived from the Gynostemma pentaphyllum. The purpose of this study was to evaluate the hepatoprotective and antifibrotic potential of Gypenoside on chronic liver injury induced by CCl 4 for 8 wks. The results indicated that the increase of SGOT, SGPT activities in CCl 4 liver injury were significantly reduced by treatment with Gypenoside. It also elevated the A/G ratio. For the study of anti-fibrotic potential, Gypenoside reduced the collagen content by 33%. These phenomena were confirmed by pathologic observation; thinner bands of liver collagen were found. The results suggest that Gypenoside has hepatoprotective and anti-fibrotic activities.Keywords
This publication has 16 references indexed in Scilit:
- Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in ratsHepatology, 1997
- Inhibition of Kupffer cell functions as an explanation for the hepatoprotective properties of silibininHepatology, 1996
- Effect of the flavanolignans of Silybum marianum L. On lipid peroxidation in rat liver microsomes and freshly isolated hepatocytesPharmacological Research, 1992
- Immunohistochemical study of extracellular matrix in acute galactosamine hepatitis in ratsHepatology, 1992
- Immunolpathology of Acute Galactosamine Hepatitis in RatsHepatology, 1990
- PREVENTION OF CCL4‐INDUCED LIVER CIRRHOSIS BY SILYMARINFundamental & Clinical Pharmacology, 1989
- Destruction of microsomal cytochrome P-450 and glucose-6-phosphatase by lipids extracted from peroxidized microsomesToxicology and Applied Pharmacology, 1978
- Albumin standards and the measurement of serum albumin with bromcresol greenClinica Chimica Acta, 1971
- The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acidArchives of Biochemistry and Biophysics, 1961
- Carbon tetrachloride cirrhosis in relation to liver regenerationThe Journal of Pathology and Bacteriology, 1936