Attenuated myogenic response and contractility in middle cerebral arteries after cardiac arrest: a randomized experimental rat study

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Abstract
Cerebral autoregulation is impaired in the postcardiac arrest period, potentially altering cerebral blood flow and exacerbating neurological injury after resuscitation. To our knowledge, the current study is the first to demonstrate that cerebral arteries exhibit reduced myogenic response, tone, and contractility in an animal model following resuscitation from cardiac arrest. These alterations in vasoreactivity appear to result, at least in part, from decreased calcium sensitivity in cerebral vascular smooth muscle cells.
Funding Information
  • Kontorchef Waldemar Paulsens og Hustru Edel Paulsens Mindefond (N/A)
  • Grosserer Valdemar Foersom og Hustru Thyra Foersoms Fond (N/A)
  • Eva og Henry Frænkels Mindefond (N/A)
  • A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal (N/A)
  • Dansk Selskab for Anæstesiologi og Intensiv Medicin (N/A)
  • Aarhus Universitet (22992)

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