Fluorimetric Determination of 3‐O‐Methylated Derivatives of Adrenaline and Noradrenaline in Tissues and Body Fluids
Author:
- 1 November 1962
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 56 (3-4) , 258-266
Abstract
A method for the determination of small amounts of metanephrine and normetanephrine in tissues and body fluids is described. The disturbing effect of adrenaline and noradrenaline is eliminated in two alternative ways: 1. By differential oxidation and subsequent ion exchange chromatography, 2. by separation on an ion exchange column. Metanephrine and normetanephrine are determined in the eluate from the ion exchange column according to the principles of the trihydroxyindole method for the fluorimetric determination of adrenaline and noradrenaline. Applications of the method on urine and brain tissue extracts are described.Keywords
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