Herbicidins from Streptomyces sp. CB01388 Showing Anti-Cryptosporidium Activity

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Abstract
A high-content imaging assay was used to screen the fraction collection of the Natural Product Library at The Scripps Research Institute for inhibitors of Cryptosporidium parvum. A chemical investigation of one strain, Streptomyces sp. CB01388, resulted in the isolation of six herbicidins (1–6), one of which is new (herbicidin L, 1). Five of the six herbicidins (1–3, 5, 6) showed moderate inhibitory activity against C. parvum, with 1 and 6 comparable to the FDA-approved drug nitazoxanide, and 2-6 showed no toxicity to the host HCT-8 cells and human HEK293T and HepG2 cells. These findings highlight the herbicidin scaffold for anti-Cryptosporidium drug development.
Funding Information
  • China Scholarship Council (201606185009)
  • Scripps Research
  • State Key Laboratory of Applied Organic Chemistry, Lanzhou University

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