New Endiandric Acid from Beilschmiedia lumutensis and Their Molecular Docking Study as a-amylase and a-glucosidase Inhibitors
Authors:
- Nur Amirah SaadNSNur Amirah Saad
- Muhammad Solehin Abd GhaniMGMuhammad Solehin Abd Ghani
- Mohammad Tasyriq Che OmarMohammad Tasyriq Che Omar
- Mohd Azlan NafiahMNMohd Azlan Nafiah
- Unang SupratmanUnang Supratman
- Desi HarnetiDesi Harneti
- Cécile ApelCécile Apel
- Marc LitaudonMarc Litaudon
- Azeana ZahariAzeana Zahari
- Khalijah AwangKhalijah Awang
- Mohamad Nurul AzmiMohamad Nurul Azmi
Open Access
- 31 March 2026
- journal article
- Published by Penerbit Universiti Sains Malaysia in Tropical Life Sciences Research
- Vol. 37 (1) , 315-339
Abstract
A preliminary study showed that an ethyl acetate extract of the bark from Beilschmiedia lumutensis (Lauraceae family) exhibited promising inhibition activities against α-amylase and α-glucosidase by in vitro assays. Subsequently, this extract revealed three new cyclic polyketides endiandric acids, namely lumutensic acid A-C (1–3). Their structures were elucidated by 1D and 2D NMR, FT-IR, HRESIMS spectroscopic data analysis and by comparison with literature data. The molecular docking study showed that lumutensic acid C (3) showed the highest binding affinity and stability with both enzymes, with strong hydrogen bonding and hydrophobic interactions, outperfoming the standard drug acarbose. These findings suggest that compound 3 could be a promising candidate for anti-hyperglycemic therapeutic development, providing further insight into the potential of B. lumutensis as a source of bioactive compounds.Keywords
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