High Helicobacter pylori numbers are associated with low eradication rate after triple therapy.
Authors:
- F M KonikoffFKF M Konikoff
- Y PeledYPY Peled
- M SantoMSM Santo
- A HallakAHA Hallak
- Y BujanoverYBY Bujanover
- E TiomnyETE Tiomny
- T GilatTGT Gilat
Open Access
Abstract
This study tested the influence of pretreatment bacterial density on the eradication rate of Helicobacter pylori with triple therapy. One hundred and thirty two patients with endoscopically confirmed H pylori positive, duodenal ulcer or antral gastritis were treated with triple therapy (colloidal bismuth/metronidazole/amoxicillin) for two weeks. Pretreatment urease activity was assessed by the 14C-urea breath test (UBT) in all patients. The mean (SD) pretreatment UBT concentration was similar in patients with duodenal ulcers (318.4 (175.0)) and patients with antral gastritis (288.9 (165.5)). Overall eradication of H pylori was achieved in 85 of 132 patients (64.4%), but was significantly different between patients with high, intermediate, or low pretreatment urease activity (37.5%, 69.5%, and 87.8% respectively). The mean post-treatment UBT value of patients in whom eradication failed was in direct correlation with the pretreatment UBT values. In conclusion, bacterial density, as assessed by urease activity, is an important factor in predicting H pylori eradication. It is suggested that the pretreatment UBT has the potential to identify patients who require modification of the standard therapeutic regimen.Keywords
This publication has 18 references indexed in Scilit:
- The urea breath test for Helicobacter pylori.Gut, 1994
- [Antimicrobial sensitivity and treatment of Helicobacter pylori infections].1994
- One week's anti-Helicobacter pylori treatment for duodenal ulcer.Gut, 1994
- Clarithromycin as monotherapy for eradication of Helicobacter pylori: a randomized, double-blind trial.1993
- GSTM1 null polymorphism at the glutathione S-transferase M1 locus: phenotype and genotype studies in patients with primary biliary cirrhosis.Gut, 1993
- 14C-urea breath test--a simple, noninvasive method for the detection of Helicobacter pylori infection.1993
- Helicobacter pyloriand Peptic Ulcer DiseaseNew England Journal of Medicine, 1991
- Drug therapy for Helicobacter pylori infection: problems and pitfalls.1990
- Cure of duodenal ulcer associated with eradication of Helicobacter pyloriThe Lancet, 1990
- 14C-urea breath test in C pylori gastritis.Gut, 1989