N-Benzoyl-protected Peptide Nucleic Acid (PNA) Monomers Expand the Range of Nucleobases Available for PNA-DNA Chimera
- 5 April 2019
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 48 (4) , 341-344
Abstract
We synthesized N-benzoyl-protected peptide nucleic acid (PNA) monomers, which are robust under the condition for deprotecting 9-fluorenylmethoxycarbonyl (Fmoc) group by piperidine but are removable by aqueous ammonia and hence totally compatible with the Fmoc-solid phase synthesis. This new invention expands the range of available nucleobase sequences, allowing us to use acid-sensitive PNA oligomers and purine nucleotides (both of which are difficult to use in the conventional methods) in the preparation of PNA-DNA chimeras to avoid the drawbacks of traditional PNAs.Keywords
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