NEK7 Cys298 is important for NLRP3 inflammasome and targetable by dimethyl fumarate
Open Access
- 21 April 2026
- journal article
- Published by Elsevier in Cell Chemical Biology
- Vol. 33 (5) , 711-719.e4
Abstract
No abstract availableKeywords
Funding Information
- National Institute of Allergy and Infectious Diseases (R01AI063331)
- National Institute of Allergy and Infectious Diseases (R01AI153110)
- National Institutes of Health
- National Institute of General Medical Sciences (R35GM141853)
This publication has 39 references indexed in Scilit:
- Consecutive palmitoylation and phosphorylation orchestrates NLRP3 membrane trafficking and inflammasome activationMolecular Cell, 2024
- NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activationCell Reports, 2024
- Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effectsiScience, 2024
- ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activationMolecular Cell, 2023
- The NLRP3 inflammasome: activation and regulationTrends in Biochemical Sciences, 2022
- The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome ActivationCell Metabolism, 2020
- Dimethyl fumarate: Regulatory effects on the immune system in the treatment of multiple sclerosisJournal of Cellular Physiology, 2018
- Metabolic Labeling of Prenylated Proteins Using Alkyne‐Modified Isoprenoid AnaloguesCurrent Protocols in Chemical Biology, 2018
- Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson’s disease by enhancing Nrf2 activityNeuroscience, 2015
- Detection of Pyroptosis by Measuring Released Lactate Dehydrogenase Activity2013