Preparations of Z-α,β-Unsaturated Amides by Using Horner-Wadsworth-Emmons Reagents, (Diphenylphosphono)acetamides

Author:

KAKaori Ando
Kaori Ando

31 December 2001

journal article
letter
Published by Georg Thieme Verlag KG in Synlett

Vol. 2001 (08) , 1272-1274
DOI:10.1055/s-2001-16072

Abstract

New Horner-Wadsworth-Emmons reagents, (diphenylphosphono)acetamides 2 react with a variety of aldehydes to give the corresponding Z-α,β-unsaturated amides stereoselectively (up to Z : E = 98 : 2).

Keywords

AMIDES
ALKENES
ALDEHYDES
HORNER-WADSWORTH-EMMONS REACTION
Z-SELECTIVE