Three Step Synthesis of Fully and Differently Arylated Pyridines
Open Access
- 9 December 2019
- journal article
- research article
- Published by Wiley in European Journal of Organic Chemistry
- Vol. 2020 (4) , 466-474
Abstract
Condensation of β‐(2‐pyridyl)enamine and α,β‐unsaturated ketone in the presence of FeCl3 under air afforded highly substituted pyridines. In this transformation, FeCl3 acted as not only an acid catalyst but also an oxidant for the intermediate dihydropyridine. The substituents could be easily modified by altering the substrates to obtain tri‐ and tetraarylpyridines including bipyridines and terpyridine. Synthesis of differently substituted pentaarylpyridines was consequently achieved via only three steps from commercially available reagents with simple experimental manipulations.Keywords
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