Acute contractile activity induces the activation of the mitochondrial integrated stress response and the transcription factor ATF4
Open Access
- 1 March 2025
- journal article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 138 (3) , 857-871
Abstract
The integrated stress response (ISR) is a mitohormetic stress response critical for the maintenance of mitochondrial homeostasis. However, its role in mediating mitochondrial adaptations with exercise-induced stress is not well established. This research demonstrates that acute contractile activity can elicit mitochondrial stress and activate the ISR to maintain mitochondrial homeostasis via the enhancement of the functioning of ATF4, illustrating an early response to exercise that promotes mitochondrial health and adaptations.Keywords
Funding Information
- Gouvernement du Canada | Canadian Institutes of Health Research (Canada Graduate Scholarship-Master's CIHR award)
- Canada Research Chairs (Cell Physiology)
- Canadian Government | Canadian Institutes of Health Research (PJT-190040)
This publication has 73 references indexed in Scilit:
- The integrated stress response as a key pathway downstream of mitochondrial dysfunctionCurrent Opinion in Physiology, 2022
- High-intensity exercise training induces mitonuclear imbalance and activates the mitochondrial unfolded protein response in the skeletal muscle of aged miceGeroScience, 2020
- Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial NetworkCell Reports, 2019
- Evolution of Mitochondria as Signaling OrganellesCell Metabolism, 2015
- Keeping the eIF2 alpha kinase Gcn2 in checkBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2014
- Activation of Calcium/Calmodulin-Dependent Protein Kinase II in Obesity Mediates Suppression of Hepatic Insulin SignalingCell Metabolism, 2013
- RETRACTED: ATF4 activation by the p38MAPK–eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cellsFEBS Letters, 2013
- Identification of GCN2 as new redox regulator for oxidative stress prevention in vivoBiochemical and Biophysical Research Communications, 2011
- Activating transcription factor 4The International Journal of Biochemistry & Cell Biology, 2008
- Exercise Stimulates c-Jun NH2Kinase Activity and c-Jun Transcriptional Activity in Human Skeletal MuscleBiochemical and Biophysical Research Communications, 1998