Involvement of Adenosine 3′,5′-Monophosphate in the Activation of Tyrosine Hydroxylase Elicited by Drugs
Authors:
- 2 March 1973
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4076) , 902-904
Abstract
Immediately after the injection of reserpine (16 micromoles per kilogram, intraperitoneally), aminophylline (200 micromoles per kilogram, intraperitoneally), and carbamylcholine (8.2 micromoles per kilogram, intraperitoneally), the concentration of adenosine 3',5'-monophosphate in adrenal medulla of rats is increased severalfold. The three drugs also cause a delayed increase of medullary tyrosine hydroxylase activity. Our results are consistent with the view that an increase of medullary adenosine 3',5'-monophosphate concentration is involved in the drug-induced increase of tyrosine hydroxylase activity in adrenal medulla. Experiments with tyramine (130 micromoles per kilogram, intraperitoneally) suggest that the increase of tyrosine hydroxylase activity and of adenosine 3',5'-monophosphate concentrations is independent of an increase in adrenal catecholamine turnover rate.Keywords
This publication has 12 references indexed in Scilit:
- Regulation of Tyrosine Hydroxylase Activity in Cultured Mouse Neuroblastoma Cells: Elevation Induced by Analogs of Adenosine 3′:5′-Cyclic MonophosphateProceedings of the National Academy of Sciences, 1972
- Rapid microassay of adenosine 3′,5′-monophosphate phosphodiesterase activityAnalytical Biochemistry, 1972
- Assay of tyrosine hydroxylase by coupled decarboxylation of dopa formed from 1-14C-l-tyrosineAnalytical Biochemistry, 1971
- Noradrenaline: Fate and Control of Its BiosynthesisScience, 1971
- Effect of Dibutyryl Cyclic-AMP on Adrenal Catecholamine-Synthesizing Enzymes in Repeatedly Immobilized Hypophysectomized RatsEndocrinology, 1971
- MICROASSAY OF ADENOSINE‐3′,5′‐MONOPHOSPHATE (CYCLIC AMP) IN BRAIN AND OTHER TISSUES BY THE LUCIFERIN‐LUCIFERASE SYSTEM1Journal of Neurochemistry, 1971
- Kinetics of release of norepinephrine by tyramineLife Sciences, 1965
- Preganglionic sympathetic activity in normal and in reserpine‐treated catsThe Journal of Physiology, 1960
- THE ESTIMATION OF SMALL AMOUNTS OF CORTICOSTERONE IN RAT PLASMAJournal of Biological Chemistry, 1958
- Die Wirkung von Lentin (Carbaminoylcholinchlorid) auf die Nebennieren der KatzeNaunyn-Schmiedeberg's Archives of Pharmacology, 1932