Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis
Open Access
- 20 March 2025
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Cancer Communications
- Vol. 45 (7) , 722-727
Abstract
No abstract availableAll Related Versions
Funding Information
- German Research Foundation (SO1141/10‐1)
- Deutsche Forschungsgemeinschaft (SO1141/10‐1)
This publication has 10 references indexed in Scilit:
- HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2Cell Death & Differentiation, 2024
- HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expressionNature Communications, 2024
- The hexokinase “HKDC1” interaction with the mitochondria is essential for liver cancer progressionCell Death & Disease, 2022
- HKDC1 promotes the tumorigenesis and glycolysis in lung adenocarcinoma via regulating AMPK/mTOR signaling pathwayCancer Cell International, 2020
- HKDC1 C-terminal based peptides inhibit extranodal natural killer/T-cell lymphoma by modulation of mitochondrial function and EBV suppressionLeukemia, 2020
- The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition poreCell Calcium, 2018
- Identification of HKDC1 and BACE2 as Genes Influencing Glycemic Traits During Pregnancy Through Genome-Wide Association StudiesDiabetes, 2013
- A functional methylome map of ulcerative colitisGenome Research, 2012
- Hallmarks of Cancer: The Next GenerationCell, 2011
- A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the MouseScience, 1990