Supplementary Figure 2 from Integrated Genetic Screening Identifies FEN1 as a Selective Vulnerability and Temozolomide Resistance Mediator in Glioblastoma Stem Cells

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Abstract
A) Pearson correlation of genetic interaction (drugZ) scores from all treated screens, presented with (right) and without (left) filtering for genes with false discovery rate (FDR) < 0.05 in at least one screen. B) ClusterProfiler analysis of cGIs (drugZ FDR < 0.05) from all screens. Reactome gene sets enriched at an adjusted P < 0.05 are shown in the dot plot, with dot size corresponding to gene ratio and dot color indicating adjusted P values. Positive and negative cGIs responsible for the only overlapping enriched pathway (DNA Repair) are listed for each model.