Tetranortriterpenoids from the Leaves of Cipadessa cinerascens

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Abstract
Seven known and six new tetranortriterpenoids, cineracipadesins A−F (1−6), were isolated from the leaves of Cipadessa cinerascens. Compound 1 has a mexicanolide-type structural skeleton with a rare 9α,11α-epoxide ring; compound 2 has a methyl angolensate-type structure with 9,11-dihydroxy groups, representing the first example of a precursor of a trijugin-type limonoid; and 3 is the first reported methyl angolensate-type limonoid with a ketone group at ring C. Their structures were determined with extensive spectroscopic analysis. X-ray crystallography confirmed the structure of 1. The ability of compounds 1−7 to inhibit the growth of the P-388 murine leukemia cell line was evaluated.

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