Pure Red-Cell Aplasia Associated with Clonal Expansion of Granular Lymphocytes Expressing Killer-Cell Inhibitory Receptors
Authors:
- Rupert HandgretingerRHRupert Handgretinger
- Andreas GeiselhartAGAndreas Geiselhart
- Arnaud MorisAMArnaud Moris
- Roger GrauRGRoger Grau
- Oliver TeuffelOTOliver Teuffel
- Wolfgang BethgeWBWolfgang Bethge
- Lothar KanzLKLothar Kanz
- Paul FischPFPaul Fisch
Open Access
- 28 January 1999
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 340 (4) , 278-284
Abstract
Killer-cell inhibitory receptors inhibit cytolysis when natural killer cells encounter cells bearing HLA class I molecules.1,2 This phenomenon explains the preferential killing by natural killer cells of tumor cells with reduced expression of HLA class I molecules.3 This finding is the basis of the “missing self” model, in which the HLA class I allele lost by the tumor cells is not available to inhibit the killer cell's lytic machinery.Keywords
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