Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients
Authors:
- Veronika Polakova VymetalkovaVVVeronika Polakova Vymetalkova
- Jana SlyskovaJSJana Slyskova
- Vlasta KorenkovaVKVlasta Korenkova
- Ludovit BielikLBLudovit Bielik
- Lucie LangerovaLLLucie Langerova
- Pavel ProchazkaPPPavel Prochazka
- Alexandra RejhovaARAlexandra Rejhova
- Lucie SchwarzovaLSLucie Schwarzova
- Barbara PardiniBPBarbara Pardini
- Alessio NaccaratiANAlessio Naccarati
- Pavel VodickaPVPavel Vodicka
Open Access
- 31 January 2014
- journal article
- Published by Springer Nature in BMC Medical Genetics
- Vol. 15 (1) , 17
Abstract
Mismatch repair (MMR) genes are known to be frequently altered in colorectal cancer (CRC). Both genetics and epigenetics modifications seems to be relevant in this phenomenon, however it is still not clear how these two aspects are interconnected. The present study aimed at characterizing of epigenetic and gene expression profiles of MMR genes in sporadic CRC patients from the Czech Republic, a country with one of the highest incidences of this cancer all over Europe.Keywords
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