STIMULATION OF IGG ANTIBODY RESPONSE IN VITRO BY T CELL-REPLACING FACTOR
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Open Access
- 1 February 1973
- journal article
- Published by Rockefeller University Press in Journal of Experimental Medicine
- Vol. 137 (2) , 547-552
Abstract
A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.Keywords
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