Discovery of a Novel Antifungal Agent in the Pathogen Box

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Abstract
Cryptococcus neoformans and Candida albicans are two major human fungal pathogens and together account for over 1.4 million infections annually, with very high mortality rates. These fungi often infect immunocompromised individuals, such as HIV/AIDS patients. In an effort to identify novel drugs with antifungal activity, we have screened the Pathogen Box for compounds with anticryptococcal and anticandidal activities. This approach led to the discovery of a promising lead compound (MMV688271) with strong antifungal potency under nutrient-limited conditions.
Funding Information
  • Deutsche Forschungsgemeinschaft (MA6248/1-1)
  • Gouvernement du Canada | Canadian Institutes of Health Research (MOP-13234)

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